Chenodeoxycholic Acid

What is Chenodeoxycholic Acid

Chenodeoxycholic acid (CDCA) is one of the major bile acids produced in the liver and plays important roles in fat digestion and cholesterol homeostasis. As a supplemental bile acid, CDCA provides benefits for optimizing fat absorption and promoting a healthy balance of gut bacteria.

Bile acids like CDCA are synthesized in the liver from cholesterol. They function as natural detergents that emulsify and solubilize fats, allowing them to be absorbed efficiently during digestion. CDCA specifically accounts for about 30-40% of bile acids.

In addition to aiding fat digestion, CDCA helps regulate cholesterol levels by inhibiting HMG-CoA reductase, a key enzyme in cholesterol synthesis . It also promotes bile flow to eliminate cholesterol from the body.

Chenodeoxycholic Acid Powder helps maintain a healthy gut microbiome balance. It inhibits growth of harmful bacteria while allowing beneficial bacteria like Lactobacillus and Bifidobacteria species to thrive.

CDCA production tends to decline with age. Supplementing with high-quality CDCA improves fat digestion and absorption while supporting healthy cholesterol levels and gut bacteria composition .

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Functions

The key evidence-based functions of supplemental CDCA include:

1. Improves Fat Digestion and Absorption

By emulsifying fats, CDCA improves the breakdown and absorption of fat-soluble vitamins A, D, E and K. This provides better nutritional status.

2. Promotes Cardiovascular Health

CDCA inhibits cholesterol synthesis and increases bile flow to eliminate cholesterol from the body. This maintains healthy cholesterol levels already in the normal range.

3. Supports Gut Bacteria Balance

CDCA selectively allows growth of beneficial gut bacteria. This improves the integrity of gut barrier function.

4. Eases Constipation

By increasing bile flow, CDCA helps improve regularity and ease occasional constipation.

5. Protects Liver Function

CDCA has been shown to protect liver cells by reducing inflammation and oxidative stress within the liver.

6. Manages Metabolic Syndrome

By improving cholesterol levels and insulin sensitivity, CDCA may help manage markers of metabolic syndrome like high blood lipids and blood glucose.

7. Aids Weight Management

CDCA supplementation has been shown to reduce body weight and BMI while decreasing fat absorption from the diet.

8. Supports Gallbladder Function

CDCA helps contract the gallbladder to aid the flow of bile needed for digestion. This supports overall gallbladder function.

Applications of Chenodeoxycholic Acid

Chenodeoxycholic acid (CDCA) is one of the major bile acids synthesized in the liver from cholesterol. In addition to its roles in fat digestion and cholesterol regulation, CDCA has found applications across a diverse range of industries due to its unique chemical properties.

Pharmaceutical Industry

In the pharmaceutical industry, CDCA is used in the synthesis of ursodeoxycholic acid (UDCA), another bile acid with therapeutic benefits. UDCA is prescribed to treat gallstone dissolution, primary biliary cirrhosis, and other cholestatic liver diseases. The starting material for industrial scale production of UDCA is CDCA.

CDCA itself also has pharmaceutical applications for treating cerebrotendinous xanthomatosis (CTX), a rare metabolic disorder. As a drug active, CDCA helps alleviate the buildup of cholesterol and cholestanol deposits associated with CTX.

Cosmetics Industry

The ability of bile acids like CDCA to emulsify fats and oils makes them useful as surfactants in cosmetic formulations. CDCA can stabilize creams, lotions, and cleansing products while also solubilizing oil-soluble vitamins and botanical extracts. CDCA has less skin irritation compared to other surfactants.

Food Industry

As an emulsifier and solubilizer, CDCA allows mixing of water-soluble and oil-soluble ingredients in food products. It helps disperse flavors evenly and prevents separation in dressings, sauces, baked goods, ice cream, and other items. CDCA has been approved for use as a food additive in various countries.

CDCA’s ability to inhibit bacterial growth also makes it useful as a food preservative. It can extend the shelf-life of perishable foods and prevent spoilage.

Nutrition Industry

In the nutrition industry, Chenodeoxycholic Acid Powder is offered as an individual supplement to provide the benefits of boosted fat absorption, cholesterol regulation, and gut health support. It helps address issues like fatty liver disease, high cholesterol, constipation, and gut dysbiosis.

CDCA is also added to multi-ingredient formulations for non-alcoholic fatty liver disease, weight management, gallbladder health, and other applications related to its physiological roles.

Animal Feed

Bile acids improve fat digestibility and nutrient absorption in livestock animals. Adding CDCA to animal feeds for poultry, swine, cattle and fish has been shown to enhance growth rates and feed conversion efficiency. This leads to higher productivity in animal agriculture.

Biofuel Production

CDCA enhances enzymatic catalysis reactions involved in the conversion of oils and fats into biodiesel. It allows higher yields of biofuels to be derived from waste oils, plant oils, and animal fats. CDCA is more effective compared to other catalytic additives.

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Packing And Shipping

● Fast lead time, with a professional freight forwarder;

● Fast service response to customers' orders;

●  25kgs/drum, Double polyethylene bags inside, and high-quality standard carton drum outside.

Certificates

We have professional product certifications and technical invention patents, including Kosher certification, FDA certificate, ISO9001, PAHS Free, HAlAL, NON-GMO, SC.

Exhibition

We have participated in SUPPLYSIDE WEST. Our products are exported to more than 30 countries including the United States, India, Canada, Japan, and so on.

Our Factory

We have perfect and mature production technology. “Filter Tank Used In The Production Process of Resveratrol”, “Method of Producing Resveratrol with Fresh Polygonum Cuspidatum”, “High-Quality Low-Temperature Concentration Tank”, “Method of Preparing Resveratrol Extract by Microbial Fermentation Technology”, all of them have obtained national invention patents.

We are Chenodeoxycholic Acid manufacturers and suppliers, if you need please contact us at Email: nancy@sanxinbio.com.

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